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Immediate Versus Delayed Loading of Single Posterior Zirconia Implants

RecruitingPhase 4Ages 18 Years - 80 YearsAllUniversity of Milan
NCT05838365 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The main aim of the present study is to investigate implant success rate after 5 years of function of immediate (Test group; within 7 days of implant placement) versus delayed (Control group; 8 weeks after implant placement) loading of two-pieces zirconia implant, placed in pristine bone without bone regeneration. Implant success rate will be defined according to Buser's criteria. Secondary endpoints: Marginal bone level (MBL) evaluation by means of standardized radiographs; Clinical evaluation of biological (e.g. Plaque Index, PI; Probing Pocket Depth, PPD, Bleeding on Probing, BOP; suppuration upon probing/palpation) and prosthetic/technical complications; Clinical evaluation of soft tissue width, keratinized tissue, marginal and interproximal soft tissue recession; Patient reported outcome measures (PROMs) by questionnaire administration:

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📋 Eligibility rules (as published)
Inclusion Criteria: * Sistemically healthy patients * partial edentulism * premolar position * molar position * Bone width and height at least 6 and 10mm, respectively. * Keratinized tissue, at least 1 mm at implant site * Full understanding of the proposed surgical treatments and the protocol schedule * Full comprehension and availability to sign the informed consent form Exclusion Criteria: * Heavy smokers (\>10 cigarettes a day) * Serious kidney or liver diseases * Uncontrolled diabetes * Bisphosphonates intake * History of radiotherapy of the head and neck * Current antiblastic chemotherapy * Congenital (primary) or acquired (secondary) immunodeficiency * Pregnant women * Connective tissue disorders Local exclusion criteria: * untreated stage III/IV periodontitis * Autoimmune diseases * oral parafunctions
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What it tests

  • Zirconia implant
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Where

1 site
San Paolo Hospital
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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