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South Africa Smoking Cessation and Engagement in HIV/TB Care Care

RecruitingNAAges 18 Years - anyAllMassachusetts General Hospital
NCT05842161 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The purpose of this study is to integrate elements from existing interventions developed by our team into a single intervention (QUIT-AD), designed to improve smoking cessation and favorable HIV/TB treatment outcomes among individuals with HIV and/or TB in Cape Town, South Africa. If feasibility, acceptability, and preliminary efficacy are demonstrated, the intervention will be ready for large-scale effectiveness/implementation testing. This program will has the potential to dramatically improve public health by increasing the smoking quit rate and facilitating favorable HIV/TB treatment outcomes among patients with HIV and/or TB in resource limited South African settings.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Aged 18 or older 2. Willing and able to provide written informed consent 3. Living with HIV, confirmed via medical record, and history of taking ART for at least three months (consecutively or non-consecutively) 4. Within 4 months of initiating or reinitiating TB treatment; positive GeneXpert test or sputum culture 5. Habitual smoker operationalized as smoking at least 4 days a week 6. Motivation (\> 5/10) to quit smoking or \> 24 hour quit past yr 7. Must be living in the catchment area for either the Town Two Clinic or the Michael Mapongwana Community Health Clinic in Khayelitsha Exclusion Criteria: 1. Current interfering untreated/unstable mental health condition (e.g., psychosis, bipolar dx) 2. Current use of non-study pharmacotherapy for smoking cessation, 3. Cognitive Behavioral Therapy for smoking cessation initiated within the past year, 4. Diagnosed with extra-pulmonary or drug resistant (MDR or XDR) TB based upon chart review
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What it tests

  • QUIT-AD
  • Enhanced Treatment as Usual
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Where

1 site
University of Cape Town
Rondebosch, South Africa
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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