Targeting Ischemia-Induced Autophagy Dependence in Hepatocellular Carcinoma

Inclusion Criteria: * Male or female, aged 18 years, meeting criteria for diagnosis of BCLC B HCC and referred to undergo TACE * HCC measuring 3 cm in minimum transverse diameter and meets LI-RADS 5 criteria based on cross-sectional imaging as determined by a board-certified, sub-specialty trained radiologist * Childs Pugh Turcotte A/B7, Performance Status 0 * Informed of investigational nature of this study with provision of signed and dated informed consent form * Stated willingness to comply with all study procedures and availability for the duration of the study Exclusion Criteria: * QT prolongation on ECG * Retinopathy on ophthalmologic examination * Females who are pregnant or breast feeding at the time of screening will not be eligible for this study * a serum or urine pregnancy test will be performed in women of child-bearing potential at screening * Prior LRT or systemic therapy to the target lesion * Contraindication to contrast enhanced MRI or metallic implant within the liver. * HCQ allergy, porphyria, uncontrolled psoriasis, and existing retinopathy * Lesion not amenable to biopsy based on pre-TACE imaging as determined by treating interventional radiologist * Serious or unstable medical or psychological conditions that, in the opinion of the investigator, would compromise the subject's safety or successful participation in the study)