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DPOS Versus GnRH Antagonist Protocol for Oocyte Accumulation in Low Ovarian Reserve Patients: An RCT

RecruitingNAAges 18 Years - 37 YearsFemaleTam Anh TP. Ho Chi Minh General Hospital
NCT05847283 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

One of the barriers in patients with diminished ovarian reserve (DOR) is the significantly reduced number of oocytes resulting in fewer oocytes collected and embryos formed. Many ovarian stimulation strategies have been proposed to improve oocyte or embryo quantity which is oocyte accumulation could be a potential option with a comparable success rate and reasonable cost. Progestin-primed ovarian stimulation (PPOS) protocol could be suggested as an alternative method of premature Luteinizing hormone (LH) prevention in IVF. It favors segment Assisted Reproductive Technology (ART) cycles such as frozen embryo transfer (FET), oocyte donor, fertility preservation, and oocyte accumulation set. The protocol is more patient-friendly and affordable than the GnRH antagonist regimen regarding LH suppression during ovarian stimulation. Many PPOS protocols have been proposed in which the three mos

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📋 Eligibility rules (as published)
Inclusion Criteria: * Woman aged between 18 and 37 years * AFC ≤ 5 and/or AMH ≤ 1.2 ng/ml * Agree to perform freeze-all strategy and single frozen blastocyst embryo transfer Exclusion Criteria: * Oocyte recipient * Indication of preimplantation genetic testing * Known allergic reactions to medications in the Study (progesterone products, GnRH antagonist….) * Basal FSH above 15mIU/mL. * Have contraindications of ART treatment (e.g. critical or acute diseases) * Retrieved sperm * Repeated Implantation failure ( ≥ 3 failed embryo transfers with good-quality embryos) * Inability to comply with the study procedures. * Patients with a history of thyroid cancer who are on hormone replacement therapy or those diagnosed with thyroid diseases at the time of eligibility assessment
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What it tests

  • Dydrogesterone priming ovarian stiumulation protocol
  • GnRH antagonist protocol
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Where

2 sites
IVFTA
Hanoi, Vietnam
Ivfta Hcmc
Ho Chi Minh City, Vietnam
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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