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Study of Thermoregulation in Exercise Heat Stroke in the Military Environment

Recruitingn/aAges 18 Years - anyAllDirection Centrale du Service de Santé des Armées
NCT05847465 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The EXPLO-MITO study is an ancillary study from the main EXPLO-CCE study (NCT04593316; IDRCB: 2020-A01967-32). The Heat Tolerance Test (HTT) is a physiological exploration that has several advantages for use in research and clinical settings. Unlike the walk-run test, it is performed under controlled conditions, both environmentally (temperature control, humidity, etc.) and in terms of effort intensity. In addition, there are published interpretation criteria for this test allowing to characterize thermoregulation profiles and to distinguish between Heat Intolerant (HI) and Heat Tolerant (HT) patients. The reproducibility of this test and its performance in a climatic chamber allows a true comparison of thermophysiological responses (heart rate, rectal and skin temperatures, skin blood flow and sweat loss), which was not possible with the run-walk test, which was more a field test vali

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📋 Eligibility rules (as published)
Inclusion Criteria: * Be included in the main EXPLO-CCE study; * Subject trained or re-trained at 2 aerobic sessions per week; * At least 2 months from the exercise heat stroke experience Exclusion Criteria: * Subject with a current medication treatment (for the control group only), * Subject with a contraindication to the ingestion of a thermal capsule, namely: * Weight less than 37 kg * Inflammatory, motor or obstructive disease of the digestive tract * History of digestive surgery * Participant requiring a CT or MRI scan prior to removal of the thermal capsule (scheduled scan) * Presence of an implantable electronic device (e.g. pacemaker)
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What it tests

  • Bike stress test
  • Heat Tolerance Test
  • Heat nociception test
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Where

1 site
Institut de Recherche Biomédicale des Armées
Brétigny-sur-Orge, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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