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Radiohistological Correlation of Thrombohemorrhagic Remodeling in the Acute Phase of Ischemic Stroke Managed by Decompressive Hemicraniectomy

RecruitingNAAges 18 Years - anyAllFondation Ophtalmologique Adolphe de Rothschild
NCT05847699 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Recent years have witnessed a change in the therapeutic paradigm of stroke with the advent of mechanical thrombectomy as the reference treatment. However, despite the achievement of effective proximal recanalization in nearly 80% of patients, nearly half of these patients have an unfavorable functional outcome. Several causes can be mentioned, such as the extent of the initial ischemic damage, the occurrence of complications related to reperfusion treatments or the occurrence of thrombosis of the downstream microvascularization. The latter is a phenomenon that has been known and studied increasingly over the last twenty years. It is the result of multiple cellular remodeling following ischemia and at the origin of an endoluminal filling by platelets, inflammatory cells and fibrin. This phenomenon introduces the fundamental difference between recanalization, i.e. the removal of the obstr

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \>18 years * Managed for sylvian ischemic stroke * Requiring brain MRI as part of the evaluation for possible decompressive hemicraniectomy (DH). Or * Having undergone a post-thrombectomy brain scan showing cortical hyperdensities and indication for a possible decompressive hemicraniectomy * Consent to participate in the study * Affiliated or beneficiary of a health insurance plan Exclusion Criteria: * Absolute or relative contraindication to gadobutrol injection (history of true allergic reaction or intolerance to gadobutrol, renal insufficiency with creatinine clearance \<15ml/min). In particular, if an allergic reaction was observed during the injection of gadobutrol performed for care during the acute phase MRI a few hours or days before. * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman
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What it tests

  • MRI sequences and biopsies
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Where

1 site
Hôpital Fondation Adolphe de Rothschild
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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