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Oral Changes With Caloric and no Caloric Sweeteners

RecruitingPhase 1, Phase 2Ages 12 Years - 18 YearsAllHospital Infantil de Mexico Federico Gomez
NCT05852145 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm microbiome in Mexican adolescents. Participants will drink on different occasions a beverage without sweetener, a beverage added with stevioside or a beverage added with sucrose. The researchers will compare the changes that each one causes in salivary pH, dental biofilm pH, dental biofilm bacterial proliferation and dental biofilm microbiome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Habitual consumption of soft drinks * Decayed, Missing, and Filled Teeth (DMF) index of at least 3 (considering as caries those lesions that are visible without the tooth needing to be dry) * Agree to participate in the study and sign informed consent * Parents sign informed consent * Any nutritional condition Exclusion Criteria: * Orthodontic treatment * Topical application of fluoride during the last 3 months * Having a motor disability that interfered with tooth brushing * Xerostomia * Antibiotic therapy during the study period * Periodontal infections
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What it tests

  • Stevioside
  • Sucrose
  • Natural water
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Where

1 site
Hospital Infantil de México Federico Gomez
Mexico City, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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