Circulating Biomarker Signatures for the Detection of Gastric Preneoplasia and Cancer

Inclusion Criteria: Common * 18 years old or highter * written informed consent prior to any study procedure * Affiliated to a social insurance system Specific to patients with gastric lesions * Untreated glandular atrophy (with or without intestinal metaplasia and/or dysplasia) and histologically diagnosed as of 2014 * Treatment naïve Gastric cancer (distal or proximal adenocarcinoma) Exclusion Criteria: Common * Autoimmune disease or disease that impacts the immune system (e.g: HIV) * Chronic inflammatory disease * Known evolutive cancer (excluding gastric cancer) * Treated in the last 3 months or currently treated with therapy that interferes with the immune system (e.g. immunosuppressive therapy) * Current treatment with long-term corticosteroid therapy * Current treatment with long-term nonsteroidal anti-inflammatory drugs * Pregnant woman or breastfeeding * Patient or healthy volunteer under legal protection (e.g. guardianship) * Patient or healthy volunteer currently participating to a clinical trial evaluating either an experimental medical product or a medical device * Patient or healthy volunteer currently in custody Specific to Healthy Volunteer * Known history of Helicobacter pylori infection * Known history of gastric lesions (i.e. chronic gastritis, gastric atrophy, intestinal metaplasia, dysplasia and cancer)