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Application of CLCVP Technique in Early Intervention of CSA-AKI

RecruitingNAAges 18 Years - anyAllNanjing First Hospital, Nanjing Medical University
NCT05855954 on ClinicalTrials.gov โ†—
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: 1. Controlled low central venous pressure (CLCVP) technique can reduce the occurrence of cardiac surgery-associated acute kidney injury (CSA-AKI) by reducing venous congestion and increasing renal perfusion pressure. 2. CLCVP technique does not increase the risk of postoperative cognitive dysfunction (POCD) during cardiac surgery. Participants who are assigned to the intervention group will receive CLCVP technique. Specific methods are as follows: First,20min after the end of cardiopulmonary bypass, on the basis of ensuring that the mean arterial pressure (MAP) โ‰ฅ 60mmHg, the patients will accept dorsal elevated position. After that, if the patient's central venous pressure (CVP) is less than 10mmHg, nitroglycerin will be pumped at 0.2ug/ (

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 years and older, who underwent cardiac surgery (coronary artery bypass grafting (CABG), heart valve surgery, heart transplant or surgical excision of intracardiac myxoma) were eligible for analyses. Exclusion Criteria: * pre-existing renal insufficiency defined by presence of abnormal preoperative serum creatinine โ‰ฅ 133 ฮผmol/L and/or preoperative diagnosis of renal insufficiency within 6 months' preoperative period. * patients with preoperative dialysis dependence within 60 days before surgery, off-pump heart surgery, prior kidney transplantation, pregnancy, as well as those under drug therapy with nitroglycerin were excluded.
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What it tests

  • controlled low central venous pressure technique (CLCVP)
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Where

1 site
Nanjing First Hospital
Nanjing, China
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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