Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects

Inclusion Criteria: * Patients with a diagnosis of periodontitis stage III or IV (grades A to C), * non-smokers or former smokers who quit at least 1 year ago, and * had not received any periodontal treatment in the 3 months prior to recruitment; * Presence of at least 1 Infrabony defect (PPD ≥ 5 mm with infrabony defect depth of ≥3mm at screening radiograph); * One and two wall infrabony defects at screening radiograph and periodontal charting. * Signed informed consent. Exclusion Criteria: * Presence of uncontrolled systemic diseases that could affect treatment outcomes such as diabetes mellitus with an HbA1C\>7%, rheumatoid arthritis or any form of immunosuppression; * Subjects requiring antibiotic prophylaxis; * 3-wall infrabony defects; * Patients that had received systemic or local delivery of antibiotic therapy 6 weeks before enrollment; * Presence of furcation defect; * Chronic intake of NSAIDs or steroids, currently; * Patients undergoing orthodontic treatment, having removable prosthetic appliances, pregnancy, tumors of the oral cavity or the presence of any psychiatric condition that could affect participation.