Multidisciplinary Evaluation and a Genome-wide Analysis in a Cohort of Idiopathic Short Stature Patients

Inclusion Criteria: * Children aged 4 to 18 years * 2 sexes * Height less than -2.5DS (standard deviations of the AFPA- CRESS/Inserm -CompuGroup Medical 2018 curve) or less than -2DS of the TCP (parental target height, corresponding to the average of parental heights +6.5 cm in boys, -6.5 cm in girls) * Normal karyotype + FISH SHOX for girls * Previously performed:celiac disease antibodies, WBC-platelets, CRP, blood ionogram, creatinine, blood calcium, blood phosphorus, ASAT, ALAT, PAL, PTH, TSH, T4L, growth hormone test normal according to the standards of the laboratory of the CHU of Montpellier * Acceptance of X-rays, in addition to those already performed as part of the care, which will not be repeated if necessary: spine front and profile, pelvis front, 1 upper limb front, 1 lower limb front F, hands and feet front * Acceptance of photographs: whole body with underwear, face face and profile, 2 faces of hands; feet, face * Acceptance of blood samples for the child and the 2 parents (trio) * Consent signed by both parents Exclusion Criteria: * Intellectual disability (IQ below 70) * Cardiac, renal, digestive or cerebral malformation, cleft lip or palate, hearing or visual impairment, epilepsy * Renal or cardiac insufficiency, digestive or chronic inflammatory pathology * Previously established genetic diagnosis