Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection

Inclusion Criteria: * Age ≥ 18 * Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \> 3 months ago or no previous history of SARS-CoV-2 infection (control group only) * Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs) * New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only) Exclusion Criteria: * SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months * Inability to provide consent or non-English speaking * Pregnancy * Any respiratory infection in last 4 weeks * PFT relative contraindications * History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism * Active malignancy undergoing treatment or history of malignancy involving the lung