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Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

RecruitingNAAges 65 Years - 84 YearsAllUniversity of Southern California
NCT05867381 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age between 65 and 84 years old; * Weight ≥ 110 pounds; * Nonsmokers for at least 1 year; * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records; * Both English and Spanish speaking participants will be included in the recruitment; * Live in the Los Angeles County. Exclusion Criteria: * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's; * Currently have active cancer treatments; * The residential house has already had HEPA filters; * Participants will move out from the current residential address in the next 2 years; * Participants will spend more than 1 month living outside the primary home; * Have any health conditions that prohibit collecting health and covariate data and biospecimens; * Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.
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What it tests

  • HEPA filtration
  • Sham filtration
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Where

1 site
Keck School of Medicine, University of Southern California
Los Angeles, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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