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Doxycycline for Helicobacter Pylori Rescue Treatment

RecruitingPhase 4Ages 18 Years - 70 YearsAllShanghai Jiao Tong University School of Medicine
NCT05874570 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Current guidelines have recommended classical bismuth-containing quadruple therapy including proton-pump inhibitor, bismuth, tetracycline, metronidazole as the empirical rescue therapy. However, tetracycline is clinically unavailable in China and the high frequency of adverse events of bismuth quadruple therapy often result in poor compliance, which limited the applicability of this recommendation. This study aimed to compare the efficacy and tolerability of a 14-day bismuth-containing quadruple rescue therapy in which tetracycline was replaced by doxycycline.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Ability and willingness to participate in the study and to sign and give informed consent * Confirmed H. pylori infection and with previous treatment failure Exclusion Criteria: * subjects naive to H. pylori treatment, * under 18 or over 80 years old * history of gastrectomy * pregnant or lactating women * severe systemic diseases or malignancy * administration of antibiotics, bismuth, antisecretory drugs, or Chinese herb medicine in the preceding 8 weeks
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What it tests

  • Esomeprazole
  • Bismuth Potassium Citrate
  • Tetracycline
  • Doxycycline
  • Metronidazole
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Where

1 site
Renji Hospital, School of Medicine, Shanghai Jiao Tong University
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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