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Confirming Permanent Lack of Blood Flow to the Brain During A-NRP DCC Organ Transplant

Recruitingn/aAges 18 Years - 75 YearsAllWestern University, Canada
NCT05884736 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study aims to evaluate the surgical technique used in Abdominal Normothermic Regional Perfusion (A-NRP) in death determination by circulatory criteria (DCC) organ donors. The proposed study will demonstrate that there is no resumption of brain blood flow or activity during the A-NRP procedure. This will be assessed using multimodal neuromonitoring protocol that enables continuous focused monitoring of brain blood flow and activity during A-NRP. This will provide evidence that brain blood flow and activity does not resume during NRP and ensure donor safety in using this technique in standard of care practice.

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📋 Eligibility rules (as published)
Inclusion Criteria: * ≤ 18 years of age * Potential DCC donors whose families/surrogate decision makers have consented to DCC organ donation according to current criteria of the participating transplant programs. These may include patients donating a liver, kidneys, pancreas, and/or lungs; please see Appendix A for organ specific donor inclusion criteria. Exclusion Criteria: * \< 18 years of age * DCC donors who proceed to donation following medical assistance in dying or those who are able to provide first-person consent at the time of donation * Injuries that anatomically preclude the use of neurological monitoring
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What it tests

  • Neuromonitoring
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Where

2 sites
London Health Sciences Centre
London, Canada
Toronto Western Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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