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Novel Targetable BIOmarkers in ANorexia NervosA

Recruitingn/aAges 18 Years - 60 YearsAllUniversity Hospital, Basel, Switzerland
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In plain words

What the trial is, and whether it could suit you

The overall aim of this present study is to evaluate Growth Differentiation Factor-15 (GDF-15) and inflammatory cytokines as a possible novel and readily treatable target for the successful therapy of Anorexia Nervosa (AN). Therefore, GDF-15, neuronal and glial damage markers such as Neurofilament light chain (Nfl) and Glial fibrillary acidic protein (GFAP) and cytokines (such as Tumor necrosis factor alpha (TNF-ฮฑ), Interleukin-6 (IL-6), and Interleukin 1ฮฒ (IL-1ฮฒ) levels will be assessed in the serum as well as in the cerebrospinal fluid of patients with diagnosed restrictive AN with and without exercising behavior compared to sex- and age-matched healthy controls to consolidate previous findings and to identify the main site of production of GDF-15 and cytokines in AN.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, non-exercising subtype Inclusion criteria: * Age 18-60 years * Written informed consent * BMI 10-16 kg/m2 N=8 adult male and female patients with confirmed diagnosis of anorexia nervosa restrictive type, exercising subtype will be included in this study. Inclusion criteria: * Age 18-60 years * Written informed consent * BMI 10-16 kg/m2 N=16 control participants, sex- and age-matched to the individual anorexia nervosa patients. Inclusion criteria: * Age 18-60 years * Written informed consent * BMI 19-24.9 kg/m2 Exclusion Criteria: * Use of antibiotics within the last 31 days * Current illicit drug abuse including daily marijuana or CBD (cannabidiol) consumption (โ‰ค 24 g of alcohol per day allowed) * Any kind of severe chronic disease other than AN (e.g. active cancer disease) * Severe renal impairment (e.g. estimated glomerular filtration rate \<30 ml/min/m2) if resulting from another disease than AN * Known liver cirrhosis or other severe liver impairment if resulting from another disease than AN * Acute upper respiratory tract infection within the last 31 days * Uncontrolled dysthyroidism * Uncontrolled hypertension * Current pregnancy/lactation or current treatment for in vitro fertilization * Inability to understand the study information, to sign the consent form and to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc.
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What it tests

  • Not listed
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Where

1 site
University Hospital Basel
Basel, Switzerland
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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