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Endo-epicardial vs Endocardial-only Catheter Ablation of Ventricular Tachycardia in Patients With Ischemic Cardiomyopathy (EPIC-VT)

RecruitingNAAges 18 Years - anyAllRennes University Hospital
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In plain words

What the trial is, and whether it could suit you

Radiofrequency ablation of ventricular tachycardias (VTs) is the gold standard treatment of refractory VTs in patients with ischaemic heart disease. In this setting, ablation is usually performed endocardially. However, even after a procedural success there is a high risk of recurrence, particularly due to the inability to create transmural lesions. Indeed, only the endocardium of the LV has been ablated, while a significant part of the arrhythmia substrate may be located on the other side of the myocardial thickness, on the epicardial side of the LV. First described in 1996, epicardial ablation, performed via a percutaneous subxyphoid approach, has since undergone considerable development. Electrophysiologists often use a double endo- and epicardial approach as first line therapy for the ablation of VTs complicating myocarditis or arrhythmogenic dysplasia of the right ventricle, where

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients over 18 years of age 2. 1st radiofrequency ablation of VT complicating ischaemic heart disease 3. Patients with an ICD and remote monitoring 4. Having, for women of childbearing age, effective contraception until discharge from hospital 5. Have given their free and informed consent in writing 6. are affiliated to or have health insurance Exclusion Criteria: 1. History of cardiac surgery compromising the epicardial approach (coronary artery bypass grafting, valve replacements, or other surgeries that may have caused pericardial adhesions) 2. Presence of a left intraventricular thrombus found during pre-procedure imaging 3. Anticoagulant therapy that cannot be temporarily discontinued 4. Double antiplatelet therapy that cannot be temporarily replaced by single antiplatelet therapy 5. History of pericarditis 6. Previous thoracic radiotherapy 7. Contraindication to general anaesthesia 8. Pregnant or breastfeeding woman 9. History of heparin-induced thrombocytopenia type 2 (as injection is required during the procedure) 10. Person under legal protection (safeguard of justice, curatorship, guardianship), deprived of liberty, or unable to express consent
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What it tests

  • Endo-epicardial ablation
  • endocardial ablation only
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Where

12 sites
CHU de Bordeaux
Bordeaux, France
Centre Hospitalier Universitaire de Caen
Caen, France
Centre Hospitalier de Clermont-Ferrand
Clermont-Ferrand, France
Centre Hospitalier Régional Universitaire de Lille
Lille, France
Hospices Civils de Lyon
Lyon, France
CHU de Nantes
Nantes, France
Hôpital Européen Georges Pompidou
Paris, France
Hôpital Universitaire La Pitié-Salpêtrière - Paris
Paris, France

…and 4 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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