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Utility of PCD Diagnostics to Improve Clinical Care

Recruitingn/aAges 2 Years - anyAllConnecticut Children's Medical Center
NCT05889013 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This cross-sectional and longitudinal observational study is to gather data on the utility of tests that are used to make a diagnosis of primary ciliary dyskinesia (PCD). There is new testing available, called nasal nitric oxide testing, that non-invasively measures nitric oxide levels in the sinus cavity. Individuals with PCD characteristically have low levels, but this testing does not have extensive data from everyday clinical practice. The objective of this proposal is to improve the diagnostic approach to children and adults with clinical concerns for primary ciliary dyskinesia (PCD).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 2 years of age * Must have two of the following clinical history points: * Neonatal respiratory distress * Chronic nasal congestion/runny nose * Chronic cough * Situs/laterality defects * Bronchiectasis * Ability to provide informed consent or consent of parent/guardian and ass Exclusion Criteria: * Recent history of sinus surgery or bloody nose in the past week * Age \< 2 years of age * Inability to tolerate probe in nose * Sinusitis or other respiratory exacerbation currently being treated with antibiotics * Admitted to hospital for respiratory exacerbation (inpatient status) * Inability to understand the requirements of the study or be unwilling to provide written informed consent (as evidenced by signature on an informed consent document approved by the IRB) * Any other reason for which the study investigators feel the patient is not a good candidate to complete the testing
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What it tests

  • Nasal Nitric Oxide testing
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Where

1 site
Pulmonary Division
Hartford, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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