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Circulating Tumor DNA Guided Treatment Monitoring in Advanced Lung Cancer

RecruitingNAAges any - anyAllZealand University Hospital
NCT05889247 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The study is a prospective randomized interventional study including patients with advanced non-small cell lung cancer, receiving immunotherapy, with the aim of optimizing treatment monitoring. The study aims to investigate the clinical utility of liquid biopsy monitoring in order to reduce the numbers of inefficient treatments and needless toxicity - and to explore the cost-effectiveness and cost-utility of introducing liquid biopsy monitoring in daily clinical practice.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Newly diagnosed, histologically verified, Non-Small Cell Lung Cancer (NSCLC) * Advanced or locally advanced disease without curative intended treatment options * Age \> 18 years * Eastern Cooperative Oncology Group (ECOG) score of Performance Status (PS) 0-1 * Measurable disease according to the iRECIST criteria version 1.1. * Eligible to first line immunotherapy (monotherapy) * Signed informed consent Exclusion Criteria: * Targetable alterations in EGFR, ALK or ROS-1 * Other active cancers
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What it tests

  • Circulating tumor DNA treatment monitoring
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Where

5 sites
Department of Clinical Oncology
Hillerød, Denmark
Department of Clinical Oncology and Palliative Care
Næstved, Denmark
Department of Clinical Oncology and Palliative Care
Roskilde, Denmark
Department of Oncology
Aalborg, Denmark
Department of Oncology
Vejle, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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