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The LYMPH Trial - Microsurgical Versus Conservative Treatment of Chronic Breast Cancer Associated Lymphedema

RecruitingNAAges 18 Years - anyAllUniversity Hospital, Basel, Switzerland
NCT05890677 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, (Lymphedema Functioning Disability and health questionnaire for upper limb lymphedema)) 15 months after randomization (and therefore about one year after surgery) compared to conservative treatment only for patients with chronic lymphedema (LE)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Written informed consent. * Patients ≥ 18 years of age. * Former diagnosis of breast cancer. * Clinical diagnosis of chronic Breast Cancer-Related Lymphedema (BCRL) (persisting for more than 3 months) classified as ≥ Stage 1, according to ISL. * Minimum of 3 months Conservative Complex Physical Decongestion Therapy. * Ability to complete the QoL questionnaires. * Willingness to undergo surgery. Exclusion Criteria: * No indication for lymphatic surgery according to clinical judgment of the treating surgeon (individual reasons will be specifically documented). * Primary congenital Lymphedema or non-BCRL. * Previous surgical BCRL treatment on the side intended for intervention.
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What it tests

  • Surgical Intervention
  • Conservative Complex Physical Decongestion Therapy
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Where

36 sites
Yale School of Medicine
New Haven, United States
Harvard Medical School
Boston, United States
Mayo Clinic
Rochester, United States
Washington University School of Medicine in St. Louis
St Louis, United States
University Clinics St.Pölten
Sankt Pölten, Austria
Krankenhaus Göttlicher Heiland GmbH
Vienna, Austria
Brussels University Hospital
Brussels, Belgium
University of Ghent
Ghent, Belgium

…and 28 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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