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A Novel Integrative Non-invasive Embryo Selection Approach for IVF Based on MK-RS Analysis

RecruitingNAAges any - anyAllChinese University of Hong Kong
NCT05896709 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

During assisted reproductive technology treatment, embryo selection is an important process that may affect the clinical pregnancy rate. Many assisted reproductive technology units over the world have tried different approaches to increase the clinical pregnancy rate. Conventionally, the morphology of the embryo is assessed by the embryologist with naked eyes only. Nowadays, artificial intelligence (AI) has been used to assist in morphological assessment of the embryo. Our pilot study showed that the AI-enhanced morphokinetic (MK) analysis increased the accuracy in embryo selection by \~9%, while the detection rate for abnormal chromosomes in embryo has also been increased by Raman spectroscopy (RS) analysis. The combined MK-RS analysis will be able to complete embryo assessment within 5-6 days after fertilization. This method needs shorter time and is at lower cost when compared to inva

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients undergoing IVF/ ICSI treatment 2. Patients receiving the first, second or third IVF/ICSI treatment cycle 3. Patients and their partners willing to sign the informed consent agreement 4. Patients having at least three normal fertilised embryos on the day of the fertilization check 5. Consecutive women undergoing IVF treatment 6. Patients planning to use a time-lapse incubator for embryo culture Exclusion Criteria: 1. Day one human embryos with blur imaging 2. Large obstructions in the embryo area 3. More than half of the embryo area is blocked by the well or degeneration 4. Patients with more than half of the embryos without sufficient spent culture medium for RS analysis 5. Patients with known genetic diseases
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What it tests

  • MK-RS
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Where

1 site
The Chinese University of Hong Kong
Hong Kong, Hong Kong
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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