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High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic Stroke

Recruitingn/aAges 40 Years - anyAllGeneral Hospital of Shenyang Military Region
NCT05897645 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intracranial atherosclerotic disease is the most common cause of ischemic stroke in Asia, also in China. Currently, despite vascular recanalization therapy, statins are one of the main drug choices for treating atherosclerotic plaque. High resolution magnetic resonance imaging (HRMRI) can accurately assess the status of intracranial and extracranial arterial plaque, and has high consistency with histopathology. Thus, HRMRI technology has been widely used to monitor the efficacy of drug treatment for atherosclerotic plaque in clinical trials or practice. As a non-invasive technique, HRMRI make it possible to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery in vivo. It can quantitative analysis including components such as lipid-rich necrotic core, fiber cap thickness, intra-plaque hemorrhage, calcification, etc. Therefore, it is crucia

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📋 Eligibility rules (as published)
Inclusion Criteria: * 1\. Patient age ≥40 years * 2\. Time of stroke onset: within 2 week * 3\. Baseline NIHSS score ≤16 * 4\. Ischemic stroke confirmed by head CT or MRI * 5\. Premorbid mRS ≤1 * 6\. The degree of stenosis of extracranial arteries including internal carotid artery, vertebral artery on the lesion side ≤50% * 7\. The culprit plaque or possible culprit plaque with plaque burden of 40% or more found by HRMRI in the proximal part of the middle cerebral artery M1 segment or basilar artery of ipsilateral lesion * 8\. Signed informed consent Exclusion Criteria: * 1\. Intracranial hemorrhage found by head CT * 2\. Had a contraindication to MRI,or could not complete required MRI sequences * 3\. Intracranial tumor, arteriovenous malformation, or aneurysm * 4\. Comorbidity with any serious diseases and life expectancy is less than one year * 5\. Pregnancy * 6\. Patients not suitable for this clinical studies considered by researcher
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What it tests

  • Registration
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Where

1 site
Department of Neurology, General Hospital of Northern Theater Command
Shenyang, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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