Comparison of the Effectiveness of Two Different Surgical Therapeutic Protocols of Peri-implantitis

Inclusion Criteria: General Inclusion Criteria: * Participants ≥ 18 years and ≤ 80 years of age * Non-smokers based on the patients' self-reported smoking status, defined as patients who had never smoked or had quit smoking at least 2 years ago * Implants in function for more than 1 year after suprastructure connection Inclusion Criteria for implants diagnosed with Peri-Implantitis: * Presence of at least one implant diagnosed with peri-implantitis defined as presence of bleeding on probing and/or suppuration, probing pocket depth ≥6 mm and ≥3 mm of detectable bone loss after initial re-modelling * Absence of implant mobility * in participants with more than one implant, the implant with the worst clinical condition will be studied. Inclusion Criteria for implants diagnosed with Peri-Implant Health: * Absence of peri-implant signs of inflammation (redness, swelling) * Lack of bleeding on probing * Absence of bone loss beyond crestal bone level changes resulting from initial remodeling, which should not be ≥2 mm Exclusion Criteria: * Smokers * Uncontrolled diabetes mellitus (HBA1c \>7) * Treatment with bisphosphonates * Needing antibiotic prophylaxis * Currently pregnant or breast-feeding women * History of systemic administration of antibiotic treatment during the preceding 3 months * Systemic conditions that contraindicate treatment * Use of medications known to induce gingival hyperplasia