AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)

Recruitingn/aAges 18 Years - 75 YearsAllGroupe d'Etude Therapeutique des Affections Infla…
💬

In plain words

What the trial is, and whether it could suit you

Multicenter prospective cross-sectional study of CD patients, its aim is the construction of an objective and reproducible system for evaluation of Transmural healing in Crohn's Disease (CD). Primary objective : Objective definition of depth or grade of transmural healing in relation to radiologic signs observed during Magnetic Resonance Enterography (MRE) in CD

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * ≥ 18 years of age * Patient diagnosed with CD for more than 6 months with histological confirmation available in his medical record. * Indication for MRE based on routine clinical practice validated by the treating physician * Any CD treatment will be authorized, such as biologicals (infliximab, adalimumab, vedolizumab, ustekinumab…), or immunomodulators (azathioprine, 6-mercaptopurine, methotrexate…). * The subjects sign and date a written, informed consent form and any required privacy authorization prior to the initiation of the study. * A subject can be enrolled into the study only if the grade of TH (assessed by the LRP) corresponding to the subject is not already fulfilled. Exclusion Criteria: * Pregnancy during the study * People unable to give consent (because of their physical or mental state) * Absence of written consent * Ulcerative colitis or unclassified IBD * Specific postsurgical settings: ileoanal anastomosis, ileostomy or colostomy. * Less than 3 evaluable ileocolic segments or more than 3 resected ileocolonic segments (not counting ileocecal valve) * Severe obstructive symptoms * Symptomatic intra-abdominal abscess * Contraindication for MRI * Isolated perianal disease without luminal location * MRE images of poor quality, based on previously defined criteria
💊

What it tests

  • Magnetic Resonance Enterography (MRE)
📍

Where

18 sites
CHU de Liège
Liège, Belgium
CHU Amiens-Picardie (site Sud)
Amiens, France
CHU de Bordeaux - Hôpital Haut-Lévêque
Bordeaux, France
APHP - Hôpital Ambroise Paré
Boulogne-Billancourt, France
CHU de Clermont-Ferrand - Hôpital d'Estaing
Clermont-Ferrand, France
APHP - Hôpital Louis Mourier
Colombes, France
CHRU de Lille - Hôpital Claude Huriez
Lille, France
CHU Limoges Dupuytren
Limoges, France

…and 10 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy