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Air Pollution and Cardiovascular Disease in Qatar: an Interventional Study to Reduce Blood Pressure

RecruitingNAAges 18 Years - 65 YearsAllWeill Cornell Medical College in Qatar
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In plain words

What the trial is, and whether it could suit you

The main objective is to determine if in-home portable air cleaners provide persistent reductions in PM2.5 exposures and improvements in systolic blood pressure and biochemical parameters over one week in patients with metabolic syndrome or type 2 diabetes residing in Qatar.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥18 and less than 65 years old * Living in a single residence (home, apartment) located anywhere in Qatar * Mild systolic hypertension: screening visit systolic BP 130 to 159 mm Hg (off treatment or taking ≤ 2 BP medications that have been stable without changes during prior one week) * Either: Type 2 diabetes patients (HbA1c \> 6.5%) OR Non-type 2 diabetes patients with two or more additional criteria for the metabolic syndrome, * Waist circumference ≥102 cm if male and ≥88 cm if female * Fasting triglycerides ≥150 mg/dL (or taking a triglyceride-lowering medication) * HDL-C ≤ 40 mg/dL if male and ≤ 50 mg/dL if female (or taking an HDL-raising medication), * Fasting glucose ≥100 mg/dL (or taking an antidiabetic medication) Exclusion Criteria: * Pregnancy (self-reported) * ≥stage 4 kidney disease (estimated glomerular filtration rate \<30 ml/min). * A medical condition placing the participant at risk from participation (per investigators) * Expected overnight travel outside their residence during the study * HEPA filter within the ACs of the residence (self-reported) or individual use of HEPA filter filter * Unable to comprehend/sign an informed consent * Lung disease requiring oxygen * Cancer receiving treatment. * Type 1 diabetes or MODY diabetes * Screening visit: BP ≥160/100 mm Hg * Medication changes in the past week. If participants are on medications for high BP or hyperlipidemia, they will need to have had stable therapy for at least one week with no planned changes during the study * Left upper arm circumference \>17 inches as this will make BP levels inaccurate with the home monitor used * Acute illness or infectious symptoms within the prior 4 weeks.
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What it tests

  • Air cleaners with HEPA filter
  • Air cleaners without HEPA filter
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Where

1 site
Hamad Medical Corporation
Doha, Qatar
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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