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Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Recruitingn/aAges 21 Years - 65 YearsAllWashington University School of Medicine
NCT05905705 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic. Exclusion Criteria: * Diagnoses of schizophrenia or schizoaffective disorders. * Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.
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What it tests

  • Electroencephalography (EEG)
  • Quantitative Measurements of Sleep Microstructure
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Where

1 site
Washington University School of Medicine/Barnes-Jewish Hospital
St Louis, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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