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Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis- Magnetic Resonance Imaging

Recruitingn/aAges 18 Years - anyAllYale University
NCT05907629 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

CAPTIVA-MRI is an observational multimodal MR imaging study that is ancillary to the CAPTIVA trial \[a 3-arm, double-blind Phase III trial conducted at approximately 115 StrokeNet sites randomizing patients with stroke attributed to 70-99% intracranial atherosclerotic stenosis (ICAS) to aspirin plus ticagrelor, clopidogrel, or rivaroxaban.\] The primary goal of this ancillary study is to determine if MRI biomarkers can potentially identify ICAS patients who fail best medical management. The CAPTIVA-MRI study leverages the CAPTIVA trial design and implementation to capture information that will inform and facilitate the next generation of ICAS trials and the management of patients with ICAS.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Enrollment in the CAPTIVA trial: nondisabling symptomatic ischemic infarct stroke within 30 days secondary to 70-99% stenosis of the intracranial ICA, MCA, BA or VA * Ability to obtain baseline study MRI within 14 days of CAPTIVA enrollmen Exclusion Criteria: * Unable or unwilling to undergo MRI, including pacemaker or other MRI contraindications per American College of Radiology guidelines62 * Gadolinium contrast allergy or acute or chronic kidney disease with eGFR\<30 ml/min/1.73m2
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What it tests

  • MRI
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Where

28 sites
University of Alabama Hospital
Birmingham, United States
University of Colorado Hospital
Aurora, United States
Hartford Hospital
Hartford, United States
Yale New Haven Hospital
New Haven, United States
MedStar Washington Hospital Center
Washington D.C., United States
Baptist Medical Center Jacksonville
Jacksonville, United States
Jackson Memorial Hospital, Miami
Miami, United States
Cleveland Clinic Tradition Hospital
Port Saint Lucie, United States

…and 20 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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