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Combined Respiratory Training in Persons With ALS

RecruitingNAAges 18 Years - 90 YearsAllNova Southeastern University
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In plain words

What the trial is, and whether it could suit you

The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed: 1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS. 2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment. 3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: 1. A diagnosis of probable or definite ALS in accordance with the Revisited El-Escorial Criteria. 2. Disease duration from symptom onset of โ‰ค 2 years, 3. Lung volume recruitment and expiratory muscle strength training naรฏve, 4. Reduced peak cough flow (% predicted for age and gender). Exclusion Criteria: 1. History of stroke, head and neck cancer or other concomitant disorder that might contribute to dysphagia or respiratory impairment. 2. Use of prescription cough assist or non-invasive volume ventilation devices. 3. Enrollment in another research investigation that might impact cough or respiratory function. 4. Diagnosis of frontotemporal dementia or advanced cognitive impairment. 5. Tracheostomy placement/Use of invasive mechanical ventilation. 6. Contraindications for respiratory training (i.e., history of pneumothorax, severe chronic obstructive pulmonary disease).
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What it tests

  • Respiratory Muscle Strength Training (LVR+EMST)
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Where

1 site
Nova Southeastern University
Fort Lauderdale, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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