🌐 EnglishEN

AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway

RecruitingNAAges 12 Years - 45 YearsAllFirst Affiliated Hospital of Zhejiang University
NCT05913960 on ClinicalTrials.gov ↗
💬

In plain words

What the trial is, and whether it could suit you

Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of depression. Theta-burst transcranial magnetic stimulation (TBS) model significantly shortened the duration of physical therapy treatment, and iTBS under the accelerated model (The latter is referred to as aiTBS)showed promising therapeutic effect. However, whether aiTBS has a better and faster curative effect in the first untreated or recurrent unmedicated MDD patients and the mechanism of its alleviation of depressive symptoms remains unclarified. This project intends to verify changes in CAMKII levels, CAMKII molecules and GABA receptors in brain-derived exosomes in normal controls and patients who received sham, aiTBS and high-frequency (10Hz) stimulation respect

Sign in to get the eligibility rules as simple questions to take to your doctor.

Sign in
📋 Eligibility rules (as published)
Inclusion Criteria: * Sign a written informed consent to participate in the trial and receive treatment; * Major depressive disorder diagnosis; * Hamilton depression scale (HAMD - 24) 24 total score 20 points or more; * First episode or recurrence of depression patients, not taking psychiatric drugs; * The han nationality, right-handed; * Junior high school or above; Exclusion Criteria: * Other organic mental disorders and mental retardation and other severe mental disorders; * Infection, trauma, and autoimmune diseases or other possible interference test evaluation of disease; * Alcohol and drug dependence or is being treated for a hormone drugs patients; * Craniocerebral injury; * Seizure or a family history of epilepsy; * Pregnancy and lactation women; * All landowners had a metal and MRI contraindications or MRI examination revealed abnormal brain structure.
💊

What it tests

  • sham stimulation
  • accelerated intermittent theta burst stimulation
  • high frequency stimulation
📍

Where

1 site
the First Affiliated Hospital,Zhejiang University School of Medicine
Hangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy