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The Effects of Specific tDCS on Cognition in MCI

RecruitingNAAges 45 Years - 80 YearsAllIstanbul Medipol University Hospital
NCT05919485 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

INTRODUCTION: Mild cognitive impairment (MCI) is a critical transitional stage in dementia related disorders. Dorsolateral prefrontal cortex (DLPFC), and the lateral parietal (LPC) cortex are subjected to neuropathological changes in MCI. Parietal memory network (PMN) integrity alterations and default mode network (DMN) alterations also occur in MCI. Transcranial direct current stimulation (tDCS) is a promising neuroprotective tool that modulates functional connectivity and might be useful to interfere with cognitive decline in relation to amnestic MCI (aMCI) and Parkinson's disease-MCI (PD-MCI) when applied to DLPFC and LPC. METHODS: This is a multicenter, randomized, and controlled study evaluating the effectiveness of anodal tDCS (atDCS ) applied bilaterally to the DLPFC/F3-F4 and LPC/ P3-P4 for 5 sessions with a total of 10 sessions in 14 days. The stimulation will be delivered wi

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Providing an informed consent; 2. Literate and between 45-80 years of age; 3. 60 females and 60 males; 4. Diagnosed with PD based on criteria suggested by UK Parkinson's Disease Society, Brain Bank and PD-MCI in accordance with the diagnostic criteria suggestions by Litvan; 5. Diagnosed with aMCI based on diagnosis criteria (CDR\>0.5) suggested by Petersen; 6. On a stable pharmacological treatment minimum for one month with no washout period. Exclusion Criteria: * Illiterate or education level less than primary school * Having an existing and/or prior neurological disease; psychiatric disease or head trauma; and/or irreversible hearing or sight problems or other medical illness (e.g. diabetes mellitus, hypertension); * Exhibiting signs of dementia for PD group ; * Having medical issues that prevent undergoing fMRI or for tDCS application.
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What it tests

  • tDCS
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Where

1 site
Alanya Alaaddin Keykubat Üniversitesi
Antalya, Turkey (Türkiye)
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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