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Improved Muscle Metabolism by Combination of Muscle Activation and Protein Substitution ( IMEMPRO )

RecruitingNAAges 18 Years - anyAllTechnical University of Munich
NCT05919940 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Intensive Care Unit Acquired Weakness (ICUAW) describes muscle weakness that occurs in around 40% of patients during an intensive care stay. The morbidity and mortality of these patients is significantly increased over a 5-year period. The aim of this study is to investigate the combined effect of early enteral high-protein nutrition and early muscle activation on muscle atrophy in critically ill patients. The study will include 40 patients (20 intervention, 20 observation) with requirement for enteral nutrition at time of inclusion. In the intervention group the maximum possible level of mobilization is carried out and muscles are activated twice a day using neuromuscular electrical stimulation (NMES). The nutrition plan of the intervention group is based on the applicable guidelines for intensive care medicine with exception of increased protein intake. The control group receives ther

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📋 Eligibility rules (as published)
Inclusion Criteria: * critically ill adults (≥ 18 years of age) * newly admitted to the ICU (\<48h) * mechanically ventilated, expected to remain for at least 72h * enteral nutrition is feasible Exclusion Criteria: * a BMI \> 30 * expected death or withdrawal of life-sustaining treatments * prior neuromuscular disease (e.g. paresis, myopathies, neuropathies) * injury or disease preventing neuromuscular electrical stimulation or early mobilization (e.g., elevated intracranial pressure, unstable spine) * a pacemaker or other electronic implant * allergy to components of NMES adhesive * have been dependent during activities of daily living prior to the hospital admission * a language barrier
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What it tests

  • Dietary Supplement: additional substitution of protein
  • Neuromuscular electrical stimulation
  • Early Mobilization
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Where

4 sites
Medical University of Vienna
Vienna, Austria
Klinikum rechts der Isar, School of Medicine, Technical Universtity of Munich
Munich, Germany
Charité - Universitätsmedizin Berlin
Berlin, Germany
Universitätsklinikum Ulm
Ulm, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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