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โ† Trials
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CSP #2026 - Beta Blocker Dialyzability on Cardiovascular Outcomes

RecruitingPhase 3Ages 18 Years - anyAllVA Office of Research and Development
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In plain words

What the trial is, and whether it could suit you

The investigators aim to determine, using a point-of-care randomized controlled trial design, if hemodialysis patients, who are randomized to metoprolol succinate (a dialyzable, beta-1 selective beta blocker), have an improved cardiovascular outcome compared to those randomized to carvedilol (a non-dialyzable, non-selective beta blocker with alpha-1 antagonist properties). The investigators will also examine intervention practices to identify components that best support engagement and sustainability.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * On hemodialysis * Received one of the following beta blockers through the VA pharmacy: metoprolol (succinate or tartrate), atenolol, labetalol, carvedilol, bisoprolol Exclusion Criteria: * Impaired decision-making capacity * Patients not receiving carvedilol who have a history of asthma * known hypersensitivity to any component of either drug * Provider unwilling to sign a new medication order for a randomized patient * No surrogate consent will be allowed
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What it tests

  • Metoprolol Succinate
  • Carvedilol
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Where

18 sites
VA Long Beach Healthcare System, Long Beach, CA
Long Beach, United States
Rocky Mountain Regional VA Medical Center, Aurora, CO
Aurora, United States
VA Connecticut Healthcare System West Haven Campus, West Haven, CT
West Haven, United States
North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, United States
Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, United States
Jesse Brown VA Medical Center, Chicago, IL
Chicago, United States
Iowa City VA Health Care System, Iowa City, IA
Iowa City, United States
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, United States

โ€ฆand 10 more on ClinicalTrials.gov.

๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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