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High-Risk prostatE Cancer radiatiOn Versus surgERy

Recruitingn/aAges 50 Years - 75 YearsMaleComprehensive Cancer Centre The Netherlands
NCT05931419 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Prospective cohort study comparing robot-assisted radical prostatectomy and external beam radiotherapy +/- androgen deprivation therapy for high-risk non-metastatic prostate cancer in terms of health-related quality of life, functional outcomes, cost-effectiveness, progression-free survival and distant metastasis-free survival.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically confirmed de novo non-metastatic high-risk prostate cancer. * cT3a-bN0M0, according to the 8th edition of the Tumour, Node, Metastasis (TNM) classification, with the exception that clinical T-stage will be based on digital rectal examination and magnetic resonance imaging (the highest stage will be used) and/or * International Society of Urological Pathology (ISUP) grade ≥4 and/or * Prostate-Specific Antigen (PSA) value at diagnosis greater than 20 ng/mL * Fit for treatment with either RARP or EBRT +/- ADT (WHO performance status 0-1) * Living in the Netherlands * Able to read and understand the Dutch language Exclusion Criteria: * Histological types other than adenocarcinoma * Diagnosis and/or treatment in a hospital abroad * Treatment with Androgen Receptor Targeted Agents (ARTA) as part of the initial treatment plan
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What it tests

  • Not listed
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Where

28 sites
Noordwest Ziekenhuisgroep
Alkmaar, Netherlands
Amsterdam UMC
Amsterdam, Netherlands
Antoni van Leeuwenhoek Ziekenhuis
Amsterdam, Netherlands
BovenIJ ziekenhuis
Amsterdam, Netherlands
OLVG
Amsterdam, Netherlands
Wilhelmina Ziekenhuis
Assen, Netherlands
Rode Kruis Ziekenhuis
Beverwijk, Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, Netherlands

…and 20 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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