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Randomized Comparison of Skeletonized Versus Pedicled Left Internal Thoracic Artery

RecruitingNAAges 18 Years - 80 YearsAllMedical University Innsbruck
NCT05931783 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Internal thoracic arteries can be harvested in skeletonized or pedicled technique. Latest research has posed a potential adverse effect of skeletonizing the internal thoracic arteries on graft patency rates and clinical outcome. Prospective, randomized, multi-centre trials are necessary to investigate the impact of harvesting technique of left internal thoracic artery (LITA) on graft patency rates and clinical outcome after coronary artery bypass grafting. The HARVITA trial compares skeletonized and pedicled harvesting technique of LITA regarding graft patency rates and patient survival.

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📋 Eligibility rules (as published)
Inclusion criteria: Primary isolated CABG patients with multi-vessel disease (defined as ≥70 % stenosis of the left anterior descending artery (LAD) and ≥50% stenosis of circumflex and right coronary territory, with or without a ≥50% stenosis of the left main artery). Exclusion criteria: * Age \> 80 years * Planned CABG without LITA use * Preoperative mediastinal radiation therapy * Emergency operation * Minimal invasive coronary artery bypass surgery * Any concomitant cardiac or non-cardiac procedures * Previous cardiac surgery * Known contrast agent allergy * Severe stenosis of the left subclavian artery/ left-sided subclavian steal syndrome * Chronic kidney disease (GFR \<60ml/min/1.73m²) * Life expectancy of less than 5 years * Pregnancy * Hyperthyroidism * Iodine allergy Intraoperative exclusion criteria: * Y/T graft off the LITA graft * LITA sequential grafting * LITA target vessel other than LAD
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What it tests

  • skeletonized harvesting technique
  • pedicled harvesting technique
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Where

8 sites
Medical University of Graz
Graz, Austria
Medical University of Innsbruck
Innsbruck, Austria
Medical University of Vienna
Vienna, Austria
University of Duisburg-Essen
Essen, Germany
University of Freiburg
Freiburg im Breisgau, Germany
University Hospital Gießen
Giessen, Germany
University of Jena
Jena, Germany
University Hospital Bern
Bern, Switzerland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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