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Effects of Novel E-cigarette Constituents on Adults TCORS 3.0

RecruitingNAAges 18 Years - anyAllYale University
NCT05932745 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years or older * Able to read and write * Some current e-cigarette use * Urine cotinine ≥200ng/ml * Willing to abstain from tobacco/nicotine use 2 hours prior to sessions Exclusion Criteria: * Current use of non-prescription substances besides nicotine, marijuana, alcohol * Any significant current medical or psychiatric condition * Known hypersensitivity to propylene glycol * Pregnant or lactating females * Uncontrolled asthma * Nut/e-liquid flavorant allergy * Current marijuana (tetrahydrocannabinol) vaping + E-cigarette or vaping use Associated Lung Injury (EVALI) symptoms * Dislike of menthol flavor
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What it tests

  • E-liquid coolant (No WS-3) for non-menthol (1)
  • E-liquid coolant (No WS-3) for low (0.1%) menthol (1)
  • E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
  • E-liquid coolant (Low [0.1%] WS-3) for non-menthol (2)
  • E-liquid coolant (Low [0.1%] WS-3) for low (0.1%) menthol (2)
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Where

1 site
JB Pierce Lab
New Haven, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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