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Intensive Treatment Versus Standard Weekly Prolonged Exposure for Adults With Post-Traumatic Stress Disorder

RecruitingNAAges 18 Years - anyAllKarolinska Institutet
NCT05934175 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare a novel, massed treatment format of prolonged exposure to gold standard trauma focused cognitive behavioral therapy (weekly delivered prolonged exposure) for post-traumatic stress disorder. The objective with this study is to investigate efficacy, mechanisms of change and cost effectiveness of intensive prolonged exposure (I-PE) in regular Swedish psychiatric care. Adult patients with post-traumatic stress disorder will be randomly assigned to receive either gold standard prolonged exposure weekly for 15 weeks or 5 days of intensive treatment with the addition of three booster sessions dispersed 1, 2 and 4 weeks after completion of the massed treatment period. Qualitative interviews will be conducted with therapists to explore their experiences of delivering intensive treatment for PTSD, with particular focus on perceived benefits and chall

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📋 Eligibility rules (as published)
Inclusion Criteria: * 18 years of age or above, * Primary PTSD diagnosis * Fluent in Swedish * Sign informed consent * Able to attend either I-PE or 15 weekly sessions of PE Exclusion Criteria: * Initiation or adjustment of any psychotropic medication within the last 4 weeks prior to commencement of treatment * Serious mental health symptoms, such as mania, psychosis, alcohol, or substance use disorders or current suicide risk warranting immediate clinical attention * Ongoing evidence-based trauma-focused psychological treatment * Ongoing trauma-related threat (e.g. living with a violent spouse)
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What it tests

  • Intensive treatment with prolonged exposure
  • Weekly delivered prolonged exposure
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Where

1 site
Traumaprogrammet, Psykiatri Sydväst
Stockholm, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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