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Leflunomide for Idiopathic Pulmonary Hemosiderosis in Children

RecruitingPhase 1, Phase 2Ages 5 Months - 18 YearsAllSun Yat-Sen Memorial Hospital of Sun Yat-Sen Univ…
NCT05937191 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The goal of this clinical trial is to compare Leflunomide in Idiopathic pulmonary hemosiderosis. The main questions it aims to answer are: * The efficacy and safety of Leflunomide in Idiopathic pulmonary hemosiderosis * The mechanism of leflunomide in treating Idiopathic pulmonary hemosiderosis Participants will be treated with leflunomide plus stroid. A comparison group: Researchers will compare the control group treated with stroid to see if the efficacy of Leflunomide would be better than control group.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age range from 6 months to 18 years old; 2. Diagnose as IPH; 3. Parents or guardians agree to treatment and sign a written informed consent form. Exclusion Criteria: 1. Individuals who are allergic to any ingredients used in leflunomide tablets; 2. Complicated with serious basic diseases (such as systemic malignant diseases, heart failure, liver and kidney failure, immune deficiency, serious infectious diseases, Lung transplantation or other patients with immediate surgical indications); 3. Patients with other lung diseases; 4. Have a history of abnormal coagulation or abnormal coagulation function in the past; 5. Clinical trial participants who have previously participated in the treatment of flumiphene; 6. Other situations where the researcher deems it inappropriate to participate in the study.
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What it tests

  • Leflunomide
  • Steroid Drug
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Where

1 site
Sun Yat-sen Memorial Hospital of Sun Yat-sen University
Guangzhou, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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