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Effects of Flumazenil on Recovery After Total Intravenous Anesthesia With Remimazolam

RecruitingNAAges 65 Years - anyAllPusan National University Yangsan Hospital
NCT05939674 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Remimazolam is a medication that has the advantage of a short half-life and reversibility with flumazenil. In clinical situations, the use of flumazenil for the reversal of sedation is common, but there is no precise indication for its administration. In this study, we aim to investigate the necessity of routine flumazenil use after administering remimazolam for intravenous anesthesia.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients over 65 years old scheduled for hip joint surgery Exclusion Criteria: * Patients with impaired consciousness or delirium before surgery * Patients who are hemodynamically unstable before surgery * Patients with a history of neurological or neuromuscular disorders or use of medications that affect neurological or neuromuscular function * Patients who have taken sedatives (anti-anxiety medications, antipsychotics, antidepressants, sleep aids) within the past 24 hours * Patients with known allergy to benzodiazepine, flumazenil * Patients with galactose intolerance, Lapp lactase deficiency, glucose-galactose malabsorption * Patients with hypersensitivity to Dextran40 * Patients who have been taking benzodiazepine for long term * Patients with end stage renal disease requiring hemodialysis * Patients with history of acute angle glaucoma * Patients with alcohol or substance dependence * ASA classification 4 or 5
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What it tests

  • Flumazenil
  • normal saline
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Where

1 site
Pusan National University Yangsan Hospital
Yangsan, South Korea
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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