Study of the Value of Trio Exome Sequencing in the Etiological Assessment of Specific Non-syndromic Language and Learning Disorders

Inclusion Criteria: * Index case suffering from one or more severe learning disorders (requiring in-school help or intensive rehabilitation), justified by neuropsychological and/or speech therapy and/or occupational therapy assessments, reviewed by experts and supplemented if necessary within the framework of the study, and not yet having undergone genetic testing. * Index case aged 3 to 40 years * Sample may be taken from index case and 2 known biological parents * Consent signed by the parents and by the index case if major * Index case and parents covered by national health insurance Exclusion Criteria: * Index case and parents have a condition which, in the opinion of the investigator, would contraindicate the subject's participation in the study. * Intellectual disability confirmed by neuropsychological testing or strongly suspected clinically in the index case and/or his/her parents * Obvious syndromic diagnosis (syndrome or antecedents having definitely led to a developmental disorder) * Persons deprived of liberty by judicial or administrative decision, * Adults under guardianship, * Persons residing in a health or social establishment * Patients in critical situations * Pregnant, parturient or nursing women * Previous array CGH and/or Fragile X testing or any other targeted genetic examination (except standard karyotype).