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Continuation Of a Study to Investigate the Effect of Thoracocentesis on Neural Respiratory Drive in Pleural Effusion

Recruitingn/aAges 18 Years - anyAllGuy's and St Thomas' NHS Foundation Trust
NCT05945043 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of this study is to better understand the relationship between pleural effusions and breathlessness in patients with unilateral pleural effusions and breathlessness who require pleural fluid removal for its management.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18 years or above * Has a unilateral pleural effusion AND 1. require thoracocentesis OR 2. chest drain insertion (main study only) OR 3. has an IPC in situ (main study only) Exclusion Criteria: * Inability to consent * Any contraindications to the proposed pleural procedure * Haemodynamic or clinical instability that precludes from the safe completion of required pre-procedural measurements * Inability to identify surface landmarks for surface EMG electrode placement * Past medical history of diaphragmatic paralysis (diaphragm sub study only)
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What it tests

  • Surface parasternal eletromyogram
  • Surface diaphragm electromyogram
  • Parasternal muscle ultrasound
  • Breathlessness assessment
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Where

1 site
Guy's & St Thomas' NHS Foundation Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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