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The Brain, the Bug, and the Binge: the Interplay Between Binge Drinking, Gut Microbiota, and Brain Functioning

RecruitingPhase 2Ages 18 Years - 23 YearsAllUniversity of Minho
NCT05946083 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD). This prevalent pattern of consumption -characterized by repeated alcohol intoxications- is of special concern, as it has been associated with major neurocognitive impairments in the young brain. Recent studies indicate that alcohol may disrupt the gut microbiota (GM) and that these disruptions may lead to impairments in brain and behavior. Also, interventions with psychobiotics have been shown to result in reductions in alcohol-induced damage and in improvements on cognitive and brain functioning. Thus, the present proposal will explore the effects of BD on GM. Additionally, a GM intervention with psychobiotics both in-vivo and in-vitro, will determine whether improvements in GM composition/function may lead t

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📋 Eligibility rules (as published)
Inclusion Criteria: * College students whose native language is Portuguese; * Age 18-23 years; * Binge Drinkers: report (i) drinking 4 (for women)/5 (for men) or more drinks on one occasion at least once a month, (ii) drinking at a speed of at least two drinks per hour during these episodes (which brings blood alcohol concentration to 0.08 g/dL or above), and (iii) having an AUDIT score \< 20. * Non/Low-Drinkers: report (i) never drinking 4/5 or more drinks on one occasion and (ii) having an AUDIT score ≤ 4. Exclusion Criteria: * Use of illicit drugs as determined by the Drug Use Disorders Identification Test (DUDIT); * Alcohol abuse (i.e., AUDIT ≥ 20); * Personal history of psychopathological disorders (according to DSM-V criteria); * History of traumatic brain injury or neurological disorder; * Family history (mother/father) of alcoholism diagnosis of substance abuse; * Occurrence of one or more episodes of loss of consciousness for more than 30 minutes; * Non-corrected sensory deficits; * Diagnosis of any gut disease/problems or other medical conditions: inflammatory bowel disease, irritable bowel syndrome, Crohn's Disease, celiac disease, lactose intolerance, autoimmune disease; * Consumption of medical drugs with psychoactive effects (e.g., antidepressants, anxiolytics or benzodiazepines) during the 4 weeks prior to the experiment; * Use of any of the following drugs in the last 4 weeks: laxatives, antibiotics, anticoagulants, non-steroidal anti-inflammatory drugs, analgesics, corticosteroids; * No type of metal object implanted in the body, especially in the head (orthodontic appliances are not excluded).
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What it tests

  • Inulin Intervention
  • Maltodextrin Intervention
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Where

1 site
Psychological Neuroscience Laboratory, Psychology Research Center, University of Minho
Braga, Portugal
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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