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Tackling Disruptions to Frailty Interventions: Developing Personalized Interventions Targeted for Older Persons With Cardiac Frailty

RecruitingNAAges 21 Years - 100 YearsAllNational Heart Centre Singapore
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In plain words

What the trial is, and whether it could suit you

Background: Muscle mass loss and metabolic dysfunction, exacerbated by inactivity and nutritional inadequacies, underpin both cardiovascular disease and frailty in ageing. The investigators' proposal seeks to develop interventions in exercise and diet that are targeted for older adults with cardiac frailty. Methods: The investigators' proposal is a five-year study comprising of first phase (first 2-2.5 years) and second phase (next 2-2.5 years). In the first phase cardiac frail participants (up to N=500) from each healthcare transition (inpatient hospital, step-down community hospital, outpatient clinic/community) will be randomized to receive Intervention Sets or usual care. The second phase will scale up these programs. Three Intervention Sets A, B, and C will be implemented in the outpatient, step-down community hospital, and acute hospital settings. Diet intervention comprises meal

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * Age ≥ 21 years old * Outdoor ambulant Exclusion Criteria: 1. Bed-bound 2. Dementia (Stage 6 onwards) 3. Residing in sheltered or nursing home 4. Cancer (to avoid confounding with cardiac disease sequelae from cancer) 5. Participation in ongoing clinical trials that involve interventional drugs or devices 6. Uncontrolled hypertension (systolic blood pressure ≥160mmHg and/or diastolic blood pressure ≥90mmHg) despite being on treatment for hypertension 7. Low blood pressure (systolic blood pressure \<90mmHg or diastolic blood pressure \<40mmHg) 8. Uncontrolled atrial fibrillation (controlled atrial fibrillation is allowed) 9. Ventricular arrhythmias (such as ventricular tachycardia) 10. Renal failure on dialysis 11. Chronic kidney disease Stage 4 and above 12. Nephrotic syndrome 13. Liver cirrhosis Child's B and above 14. Inflammatory Bowel Disease 15. Severe uncontrolled gout 16. Poorly controlled Diabetes Hba1c ≥9% 17. On warfarin 18. Presence of food allergies (such as shell-fish, prawn) 19. Patient's life expectancy is expected to be less than one year at the time of potential enrolment as assessed by the investigator 20. Nasogastric or parenteral nutrition 21. Hypertrophic cardiomyopathy 22. Cardiac amyloidosis 23. Cardiac sarcoidosis
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What it tests

  • Intervention Set A
  • Intervention Set B
  • Intervention Set C
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Where

6 sites
Alexandra Hospital
Singapore, Singapore
National Heart Centre Singapore
Singapore, Singapore
Changi General Hospital
Singapore, Singapore
Sengkang General Hospital
Singapore, Singapore
Jurong Community Hospital
Singapore, Singapore
NHG Polyclinics
Singapore, Singapore
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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