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Genetic Regulators of Bone Health That Are Unique to Vertebral Bone

Recruitingn/aAges 18 Years - 85 YearsAllUniversity of Colorado, Denver
NCT05946278 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Osteoporosis is an age related disease in which a person's bone slowly becomes weaker with time. The bones may become so weak that they break easily such as a fall from standing height. The most commonly broke bones in osteoporosis are those of the hip, the spine or the wrist. Osteoporosis runs in families meaning that genetic differences explain why some people break bones in old age and other do not. Genetic studies have been done that show the the genes associated with spine (vertebral) fractures (broken bones) and hip fractures are different, suggesting that osteoporosis of the spine is not the exact same disease as osteoporosis of the hip. Genetic studies tell us what part of the genome (i.e. genes) are associated with a disease, but do not tell us how these genes act biologically to cause that disease. In this study, we seek to determine how the genes uniquely associated with spine

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📋 Eligibility rules (as published)
Inclusion Criteria: * Men and women between the ages of 18 and 85 undergoing a multi-level spinal fusion (i.e. a T10 (or higher) fusion to the pelvis) -OR- a 3 column osteotomy with a corpectomy from for short segment surgeries -OR- a vertebral column resection (VCR) involving a corpectomy -OR- any deformity correction surgery wherein the attending surgeon determines that a large amount of bone containing trabecular elements will be removed and discarded. * Willing and able to provide informed consent Exclusion Criteria: * End stage renal disease. * Any history of cancer. * Reliance on a wheelchair for 70% or greater of their mobility for longer than 12 months. * Quadra or paraplegia due to spinal cord injury. * Current use of epilepsy medications. * Confirmed Marfans, osteogenesis imperfecta or other genetic syndrome known to impact bone formation (Guacher's, Vit D independent rickets, etc). * Current glucocorticoid use lasting longer than 3 months, or greater than 6 months lifetime use. * Current or suspected current infection associated with orthopedic hardware. * HIV or Hep C positive and or currently on anti-viral medications. * History of gastric bypass surgery and or weigh loss exceeding 100 pounds. * Primary or secondary hyperparathyroidism. * Paget's disease
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What it tests

  • Sample collection for gene expression
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Where

1 site
Univeristy of Colorado Denver
Aurora, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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