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โ† Trials
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Efficacy of Tadalafil (5mg) For Treatment of Early Storage Symptoms and Erectile Dysfunction After Endoscopic Enucleation of Prostate

RecruitingPhase 2, Phase 3Ages 40 Years - 80 YearsAllMansoura University
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In plain words

What the trial is, and whether it could suit you

From previous studies, the investigators found that sexual outcomes after prostate surgery may show insignificant improvement, remain unchanged or deteriorate in non-negligible number of patients especially those with high preoperative IIEF scores. Deterioration of erectile function could be attributed to persistence of storage symptoms specially nocturia. Several pathophysiologic mechanisms, described before, are involved in pathogenesis of LUTS and ED and one can imagine that after relief of obstruction, the erectile function should improve, however lack of improvement or even deterioration suggests that damage associated with these mechanisms is irreversible and patients may require some sort of penile rehabilitation after surgery. The investigators hypothesized that Tadalafil may enhance relief of storage symptoms and enhance recovery of erectile function after surgery for BPH. With

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๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patients' age โ‰ฅ 40 years * LUTS secondary to BOO due to BPH who failed medical treatment * International prostate symptom scores (IPSS) \>15 and bother score (QOL) โ‰ฅ 3 (according to IPSS question 8) * Peak urinary flow rate (Qmax) \<15 ml/sec. * ASA (American society of anaesthesiologists) score โ‰ค 3. * Sexually active men, not receiving PDE5I Exclusion Criteria: * Patients using nitrates, potassium channel opener, or ฮฑ1-blockers doxazosin and terazosin for control of hypertension * Patients with unstable angina pectoris, recent myocardial infarction or stroke myocardial insufficiency. * Patients with severe hepatic or renal insufficiency. * Patients who are sexually inactive. * Patients with uncontrolled diabetes mellitus or neurologic condition(eg. parkinsoism)
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What it tests

  • Tadalafil 5mg / Placebo
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Where

1 site
Urology and Nephrology Center
Al Mansurah, Egypt
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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