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Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine

RecruitingPhase 1Ages 21 Years - 65 YearsAllUniversity of California, San Francisco
NCT05962229 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In a crossover study, experienced electronic cigarette users will vape 3 different forms of nicotine: natural (derived from tobacco), synthetic, or a 50:50 mixture of both natural and synthetic. The investigators will compare nicotine metabolism, cardiovascular effects, patterns of self-administration, and participants' feelings of craving/withdrawal and enjoyment.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Healthy on the basis of medical history and limited physical examination. * Current regular user of E-Cigarettes (≥ 15 days in the past 30 days) Exclusion Criteria: * • Medications * Use of medications that are inducers of nicotine metabolizing enzyme CYP2A6 (Example: rifampicin, carbamazepine, phenobarbital, and other anticonvulsant drugs). * Use of sympatholytic medications for cardiovascular conditions including hypertension (Example: beta and alpha-blockers). * Concurrent use of nicotine-containing medications (Example: nicotine patch, lozenge, gum). * Any stimulant medications (example: Adderall) generally given for ADHD treatment. • Pregnancy * Pregnancy (self-reported and urine pregnancy test) * Breastfeeding (determined by self-report) * Women of childbearing potential must be using an acceptable method of contraception * Inability to read and write in English * A known propylene glycol/vegetable glycerin allergy * Uncomfortable with getting blood drawn
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What it tests

  • (S)-Nicotine
  • (R)- nicotine
  • Racemic nicotine
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Where

1 site
Zuckerberg San Francisco General Hospital (ZSFG)
San Francisco, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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