The MANTRA Trial (MANdibular TRauma and Antibiotic Use)

All adult patients aged 18 years or over with mandible fractures requiring surgery. Most of these patients will be identified from the A\&E department via the on-call OMFS team or seen in dedicated OMFS trauma clinics. A small proportion of our study population will be seen in an OMFS clinic following referral from GP/GDP. Inclusion Criteria: * Ability to provide written informed consent * Age≥18 years * Hospital episode of mandible fracture(s) * Planned treatment is surgery - (ORIF with titanium miniplates) Exclusion Criteria: * Isolated mandibular condylar fractures * Existing fracture site infection * Immunocompromised (transplant patients, haematological malignancies, HIV/AIDS) - a clear definition will be provided in the protocol * Pathological fracture (e.g., malignancy, osteoradionecrosis, cysts, Medication-Related Osteonecrosis of the Jaws \[MRONJ\]) * Fractures open to skin * Inability to provide written informed consent * Other injuries or infections mandating ongoing post-operative antibiotics (e.g., panfacial fractures with mandible fracture component) * Patients allergic to first and second-line antibiotic prophylaxis (as outlined above)