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Feasibility of Individualized, Model-guided Optimization of Proton Beam Treatment Planning in Patients With Low Grade Glioma

RecruitingPhase 2Ages 18 Years - anyAllUniversity Hospital Heidelberg
NCT05964569 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Low-grade glioma (LGG) represent typically slowly growing primary brain tumors with world health organization (WHO) grade I or II who affect young adults around their fourth decade. Radiological feature on MRI is a predominantly T2 hyperintense signal, LGG show typically no contrast uptake. Radiotherapy plays an important role in the treatment of LGG. However, not least because of the good prognosis with long term survivorship the timing of radiotherapy has been discussed controversially. In order to avoid long term sequelae such as neurocognitive impairment, malignant transformation or secondary neoplasms initiation was often postponed as long as possible

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age \> 18 years * histologically proven low-grade glioma * indication for definitive or adjuvant radiotherapy * ability to understand character and personal consequences of the clinical trial * written informed consent Exclusion Criteria: * previous cerebral irradiation * contraindication for contrast-enhanced MRI * neurofibromatosis * participation in another clinical trial with competing objectives
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What it tests

  • model-guided optimization of treatment plan
  • standard treatment plan, no optimization
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Where

1 site
Department of Radiotherapy, University of Heidelberg
Heidelberg, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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