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The Effect of Chronic Stress on Efficacy of ICIs in Esophageal Cancer Patients (STRESS-ESCA Study)

Recruitingn/aAges 18 Years - 75 YearsAllSecond Xiangya Hospital of Central South Universi…
NCT05967910 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic stress refers to a special emotional state caused by unexpected stress for a long time, with an increasing incidence in the population. It can cause the body to release hormones such as cortisol and adrenaline. Tumor patients often experience changes such as psychological and emotional abnormalities, decreased quality of life, and impaired social relationships. Under stimulation, patients often experience negative reactions such as anxiety or depression. Epidemiological studies have shown that stress can affect the prognosis of malignant tumors, but the effect of stress on the efficacy and prognosis of esophageal cancer is still unclear. In animal models, chronic stress leads to an increase in tissue catecholamine levels, increased tumor burden, and increased invasiveness of ovarian cancer cells in mouse models. At the same time, stress can promote tumor neovascularization in mi

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Age ≥18 years and ≤ 75 years old 2. Pathologically diagnosed as esophageal cancer 3. Patient tumor tissue samples can be obtained 4. At least one measurable lesion can be evaluated according to the RECIST 1.1 standard 5. As a newly treated patient, they have not received systematic anti-tumor treatment for locally advanced or metastatic chest tumors 6. There is no obvious abnormality in the electrocardiogram and no obvious cardiac dysfunction 7. Hematology and liver and kidney function indicators meet the requirements Exclusion Criteria: 1. Merge with other malignant tumors 2. Long term use of hormones or immunosuppressants 3. Concomitant acute or chronic mental illness 4. Patients who have been taking drugs that can alter the activity of the sympathetic nervous system for a long time or are currently taking them 5. Other malignant diseases that require systematic treatment 6. Patients who have undergone other clinical drug experiments before 7. Patients with symptomatic brain metastases
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What it tests

  • chronic psychological stress
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Where

1 site
Department of Oncology, The Second Xiangya Hospital, Central South University
Changsha, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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