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Altered Neural Pain Empathic Reactivity in NSSI Adolescents

Recruitingn/aAges 15 Years - 18 YearsAllUniversity of Electronic Science and Technology o…
NCT05968313 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nonsuicidal self-injury (NSSI) is defined as direct, deliberate bodily harm without suicidal intention. In recent years, growing evidence suggests that NSSI has become a worldwide public health issue. People with NSSI behaviors, especially adolescents, commonly exhibit emotion-related and interpersonal problems. Pain empathy represents an essential basal domain of socio-emotional processing and refers to the ability to empathize, connect and share with others' pain. However, altered empathic processing has not been systematically examined in adolescents with NSSI. To this end, the current functional magnetic resonance imaging (fMRI) study will recruit one group of NSSI adolescents (n=40) and one healthy control (HC) group (n=40), to compare their neural activity regarding pain empathy processing, which is measured by blood oxygenation level-dependent (BOLD) fMRI. The investigators includ

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📋 Eligibility rules (as published)
Inclusion Criteria: * 15-18 years * right-handed * normal or corrected normal visual acuity * meet the proposed DSM-5 frequency criteria (e.g., ≥5 days of NSSI behaviors in the past year) Exclusion Criteria: * diagnosis of borderline personality disorder, major depressive disorder, other * psychiatric disorders, etc. * high suicidal risk * recent use of medications that can affect neural activity * have received or are receiving Dialectical Behavior Therapy (DBT) other treatment for emotional problems within the past 6 months * have a contraindication to MRI scanning (e.g., metal implants, claustrophobia or other conditions that make them inappropriate for MRI scanning)
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What it tests

  • Not listed
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Where

1 site
Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China
Chengdu, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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