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IBS Personalized Diet vs. Low FODMAP Diet Randomized Control Trial

RecruitingNAAges 18 Years - 70 YearsAllWeizmann Institute of Science
NCT05972317 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Irritable bowel syndrome (IBS) is considered the most common gastrointestinal disorder in humans, with an estimated global prevalence of 11%-20% of all humans. Alterations in the gut microbiome are at the center of IBS, and microbiome-induced volatile metabolites in response to dietary exposures is believed to drive a downstream impact on susceptible hosts, thereby driving the disease. However, the characteristics and functions of these metabolites remain unknown to date. This placebo-controlled interventional study examines person-specific small molecules and bacteria driving IBS and their downstream effects on the human gut epithelium.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and Female * Age - 18-70 Exclusion Criteria: * Consumption of antibiotics 2 months prior to enrolment. * Consumption of probiotic supplements 2 weeks prior to enrolment. * Type 1 or type 2 diabetes diagnosis. * Pregnancy, fertility treatments, breastfeeding 3 months prior to the first day of the study. * Chronic disease - to the discretion of the study medical team. * Cancer and recent anticancer treatment. * Immunosuppression. * Psychiatric disorders - to the discretion of the medical team * History of gastrointestinal surgeries - to the discretion of the medical team * Inflammatory bowel diseases or gastrointestinal disorders - to the discretion of the medical team * Unstable doses of medications in the past 2 months * Alcohol or substance abuse.
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What it tests

  • Standard Low FODMAP dietary regimen
  • personalized low FODMAP dietary regimen
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Where

1 site
Weizmann institute of science
Rehovot, Israel
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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